I have a 1998 Nissan Maxima.
It feels as if someone's holding the car back and smoke comes from front right wheelwell after accelerating. It's also getting terrible gas mileage.
Is this a brake issue?
DO NOT DRIVE THIS CAR AGAIN UNTIL IT IS FIXED!
What you describe is a major problem. When a car resists moving and forcing it causes smoke, STOP. Continuing to drive it in this condition could cause major damage and/or accident/injury.
Here are a few things it could be;
You need to jack it up to see that is going on. If you are unable to work on it yourself, have it towed to a mechanic. DO NOT drive it there.