I just bought a 2000 Chevy s10. It shakes when accelerating moderately in gears 3-5 (manual transmission). If I accelerate very gently, it doesn't happen. There is also a knocking noise every 1-2 seconds when it is shaking (it sounds like it's coming from the lower driver's side of the engine bay, but I can't be sure because it only happens when the vehicle is moving).

It accelerates fine in 1st and 2nd, so I don't think the transmission is slipping. What could be causing this problem?

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    You say "just bought" so did the car do this when you took it for a road test? Why not take it back to the dealer and get them to sort it? It could possibly be an engine mount but also many other things, – Solar Mike Jul 16 '17 at 22:09
  • @SolarMike Private party purchase. – Jacob Jones Jul 16 '17 at 22:11
  • @SolarMike How many other things? I'm not sure where to start looking, so I'm hoping for a list of things to check to narrow down the problem. – Jacob Jones Jul 16 '17 at 22:13
  • Check the U joints, if they are really bad you can move the driveshaft with your hand. If they are worn but real bad you have to remove the driveshaft and manually rotate the U joints to feel for binding. – mikes Jul 16 '17 at 23:31
  • There's so many possibilities here, it could be worn tires, bad suspension, problems with the axle, the list goes on – GdD Jul 17 '17 at 7:03

The problem was the U Joints. No other fixes were necessary to stop the noise or the vibration.

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