No. Other than the hole in your pocketbook.
On a separate note, though ... if you are going out of your way to purchase all of those spark plugs, you'd be better off just getting the platinum or iridium plugs which last much longer. For half as much again, you can get a plug which will last several times longer. Some of them will even boost performance over your stock plug. Considering most newer engines have spark plugs which are good for 100k miles, it makes sense to at least consider this.
EDIT: One other thing to consider, especially for engines with aluminum heads. Every time you take the spark plug in and out of the threads, you are wearing them out just a little bit more. It is not unheard of for aluminum threads to completely strip out. The usual fix for this is to Heli-Coil the hole, which can be done while the head is on the engine, but a lot of care and time must be given to do it right without getting a lot of debris into the cylinder.