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I last replaced them with the plugs about 4 years/60-70k miles ago. I bought platinum plugs I if I remember correctly, so I still got some life on those. The car (2001 Buick Regal) is still in good shape just due for a tune up, so if the wires are due to be changed I'll add those to the list.

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up vote 3 down vote accepted

According to the 2001 Buick Regal service manual (PDF) spark plugs wires should be inspected at 100K miles, and replaced if necessary (p. 7-15).

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Thanks, I don't even know if I have this manual anymore. I see on page 7-15 I should inspect the wires every 100k, so there's my answer. – BigHomie Apr 20 '13 at 3:39
    
Anytime. I have a ton of manuals in my database =). Glad to help. – cinelli Apr 20 '13 at 5:35
1  
How exactly are you suppose to inspect them? What should you look for when you are inspecting? For me this is not a complete answer. – rana Aug 21 '15 at 16:22

spark plug wires should last a very long time, so just check them when you get the plugs done, and replace if they're worn out.

wires don't really wear with distance, it's time and heat cycles that cause the insulation to eventually degrade. usually there good for several years

look for cracking of insulation, particularly at joints. check for corrosion of terminals and if you're really motivated, check resistance (lower is better)

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